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Denver Broncos 21–17 Philadelphia Eagles

Bo Nix found a short scoring throw and JK Dobbins contributed another ground touchdown in the fourth quarter as the Denver Broncos erased a two-touchdown disadvantage to hand the Philadelphia Eagles their initial defeat of the season. Denver's defense deflected the Eagles quarterback's last-gasp pass on the contest's last snap to hand the reigning title holders to just their second loss in their previous 22 outings. Denver (three wins and two losses) caught a huge break in their rally when the Philadelphia had a crucial play called back on a formation infraction whistled against star ball carrier Barkley.

Texans Dominate Depleted Ravens in Record Win

CJ Stroud threw for 244 yards and four scoring throws, and Houston (two wins and three losses) cruised to a 44-10 win over a depleted Baltimore team, equaling both the most lopsided road win in Texans' history and the most lopsided home loss in Baltimore's annals. The Ravens (1-4) were missing two-time MVP quarterback Lamar Jackson, and that was far from their sole issue. Defensive standouts multiple defensive leaders all were absent, and the Baltimore already were weakened on defense because of a cervical issue that concluded Nnamdi Madubuike's campaign. Baltimore were also missing Pro Bowl blocker Ricard and offensive lineman Stanley.

Colts Rout Raiders in One-Sided Affair

Jonathan Taylor ran for three touchdowns and a two-point conversion, and the quarterback passed for two touchdown passes as the Indianapolis Colts overwhelmed the Raiders. This decisive advantage was Indy's largest since the 2013 season. Jones completed 20 of 29 for 212 passing yards and moved to four wins and one loss as a starter this year, surpassing his combined victory total over the past two seasons with the Giants. Taylor rushed 17 times for 66 rushing yards and caught three passes for 20 receiving yards. Indianapolis turned multiple takeaways into touchdowns. The Raiders fell to 4-1.

Dallas Cowboys 37-22 New York Jets

Dak Prescott passed for four touchdown passes, guiding the Cowboys to an easy victory over the Jets. The Cowboys put points on the board on two 90-yard drives in the second quarter, despite being without key linemen on the offensive line. Javonte Williams ran for 135 yards and a touchdown and also caught a TD pass. The Cowboys, now two wins, two losses, and a tie, rebounded from a high-scoring draw against Green Bay last Sunday. The Jets are still without a victory at 0-5 in Aaron Glenn's inaugural year as head coach.

Vikings Edge Browns in London Thriller

Minnesota wideout Addison caught a 12-yard scoring reception from the quarterback with 25 seconds left to give Minnesota a win over the Cleveland Browns at the UK venue. The 10-play, 80-yard drive gave the Vikings (three wins and two losses) a crucial victory on their overseas journey, which began with a 24-21 loss to the Steelers in Dublin last Sunday. It also spoiled the rookie's debut as starter, as the Browns first-year player positioned his squad (one win and four losses) in contention by passing for two touchdown passes. Another first-year player Quinshon Judkins rushed for 110 yards on 23 attempts. The quarterback overcame an arm issue that briefly sent him to the locker room and led two scoring drives in the second half.

Panthers Stage Epic Comeback Against Dolphins

Carolina's quarterback threw for two touchdowns and the running back rushed for 206 yards and a touchdown as the Panthers came back against the Miami Dolphins in their home stadium. Young's quick throw to the first-year receiver with under two minutes to play gave the Carolina (two wins and three losses) the decisive advantage as they matched the largest comeback to secure victory in franchise history by erasing a large deficit. The QB had a poor start, but he ended up 19-for-30 passing for 198 passing yards with an interception. The backup, filling in for the sidelined starter, did his work on the ground on 23 attempts, falling just short shy of the single-game franchise rushing record. Miami's Tua Tagovailoa completed 27 passes out of 36 for 256 yards with three touchdowns and Jaylen Waddle accumulated 110 yards through the air on six receptions and scored a touchdown, but the Dolphins (one win and four losses) dropped to 0-3 in road games.

New York Giants 14–26 New Orleans Saints

Spencer Rattler threw a long touchdown to receiver Shaheed, safety Jordan Howden returned a fumble the length of the field for a touchdown, and New Orleans defeated the error-prone Giants for the Saints' initial win under rookie coach Kellen Moore. The QB earned his first victory in 11 professional starts, passing for 225 yards without any mistakes. Giants rookie QB Dart, who secured his debut last Sunday, passed for 202 passing yards and two scores, but also committed errors three times. The Giants gave up possession five times in all, none more costly than when Bryan Bresee forced a fumble from running back Cam Skattebo, leading to the safety's touchdown. Both teams are 1-4.